Botulinum toxin has now been used in aesthetic medicine for 15 years (but its first uses in medicine date back to the 1980s) and has multiple applications in facial treatment, the best known of which is certainly its effect in reducing expression lines on the forehead, glabella and eye contour. When properly dosed, its results are extremely natural and impossible to recognise by a layman. In addition to expression lines, it can in some cases be useful for improving other aspects of the face, again linked to the action of certain muscles, such as raising the tip of the nose, opening the gaze, reducing the so-called 'gingival smile' to name but a few. But the application possibilities do not stop there and are especially not limited to the face. Botulinum toxin, in fact, is increasingly being used to control those situations where there is excessive sweating, especially when this is located in the armpits. It can also resolve, or in any case help to greatly improve, particularly complex situations such as Bruxism (continuous contraction of the masticatory muscles during the night, accompanied by teeth grinding), minimising its symptoms and thus its consequences (daytime muscular pains in the jaw and progressive consumption of the chewing surface of the teeth). The wide range of possible applications, its evident efficacy and very rapid effects make Botulinum Toxin an essential treatment in a modern, up-to-date aesthetic medicine practice. However, it requires a great deal of experience in order to reap the maximum benefits. For example, today there is still a lot of fear of this treatment, especially on the part of those who have never tried it or those who have undergone it in the past with discouraging results (e.g. with eyebrows that then rose too high, giving a 'demonised' expression). The reality is fortunately very different today. A 'reasoned' use of botulinum toxin provides a pleasant relaxing effect on the face, making it look naturally rested, without denaturing its essence.